Brain Fables: The Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them
Cambridge University Press, 7/9/2020
EAN 9781108744621, ISBN10: 1108744621
Paperback, 178 pages, 23.4 x 15.6 x 1 cm
Language: English
Originally published in English
An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. This is because diseases such as Parkinson's and Alzheimer's do not exist in biology. Yet, hundreds of clinical trials around the world are examining the potential of single therapies in thousands of people sharing one of these labels. Compounding the problem, these therapies were developed on evidence from models that do not come close to capturing the complexity of these diseases in the affected humans. These practices must end. Brain Fables is a call to refocus on understanding living and aging to create the personalized treatments each affected individual desperately needs.
Preface
Acknowledgements
1. The shaky six and the 'second reality'
2. Pieces of a puzzle?
3. Disease 'redefinition'
a tough pill to swallow
4. Disease subtypes
the promise and the fallacy
5. Protein paradox
6. The fault in our models
7. Biomarkers
the promise and the fallacy
8. Lessons from oncology
9. Symptomatic vs. disease-modifying therapies
10. The hypothesis that refuses to die
11. Our living dissonance
12. The scientific and lay narratives
13. Challenges viewed from afar
14. The moonshot
population-based studies of aging
15. Predictions for the 2020s and beyond
Epilogue. 'When will we have a cure for Parkinson's disease?â€Â
Note added at press time
References
Index.