Multiscale Modeling of the Skeletal System
Cambridge University Press, 12/15/2011
EAN 9780521769501, ISBN10: 0521769507
Hardcover, 222 pages, 25.5 x 18.1 x 1.6 cm
Language: English
Integrative approaches to biomedical research promise to advance our understanding of the human body and physiopathology of diseases. In this book, the author focuses on the skeletal system, demonstrating how multiscale modeling can determine the relationship between bone mechanics and disease. Introductory chapters explain the concept of integrative research, what a model is, predictive modeling, and the computational methods used throughout the book. Starting with whole body anatomy, physiology and modeling, subsequent chapters scale down from bone and tissue levels to the cellular level, where the modeling of mechanobiological processes is addressed. Finally, the principles are applied to address truly complex, multiscale interactions. Special attention is given to real-world clinical applications: one in pediatric skeletal oncology and one on the prediction of fracture risks in osteoporotic patients. This book has wide interdisciplinary appeal and is a valuable resource for researchers in mechanical and biomedical engineering, quantitative physiology and computational biology.
1. Introduction
2. Methodological aspects
3. The body level
4. Organ level
the bones
5. Tissue level
mineralised extracellular matrix
6. Cells level
cells-matrix interaction
7. Applications of multiscale modeling
8. Multiscale modeling
Index.