Prader-Willi Syndrome: Development and Manifestations
Cambridge University Press
Edition: Illustrated, 4/22/2004
EAN 9780521840293, ISBN10: 0521840295
Hardcover, 232 pages, 25.4 x 18 x 2 cm
Language: English
Originally published in English
Prader-Willi syndrome (PWS) is associated with an assortment of physical, behavioural and cognitive abnormalities which create a broad range of care needs. Information about the syndrome is spread across a variety of disciplines. In this book the authors seek to identify and provide the latest findings about how best to manage the complex medical, nutritional, psychological, educational, social and therapeutic needs of people with PWS. Their approach is an integrated one, centred on the PWS phenotype. Both authors have been involved in the Cambridge PWS study, which is the largest and most rounded of the cohort studies of PWS anywhere in the world. The unique data it provides is the basis of this book.
Introduction
Part I. Background
PWS, Why, What, and How To Investigate
1. Background and historical overview
2. Biological and regulatory mechanisms in PWS
3. The Cambridge PWS project
Part II. PWS Prevalence, Phenotypic Functioning and Characteristics
4. Prevalence, birth incidence and mortality
5. Relationship between genetic and clinical diagnosis
6. Phenotypic differences between the genetic subtypes
7. Cognitive function and attainments
8. The behavioural phenotype of PWS
9. Medical conditions affecting people with PWS
10. Psychiatric illness
11. Obsessions and compulsions
Part III. Minor Findings, Some Conclusions and Future Directions
12. Understanding PWS
Index.
Review of the hardback: 'It is a representative compilation of the knowledge of today ... can be recommended to all readers interested in genetics and their connections to different human functions. Even parents of children with PWS who want to know where the front line of research is will find this book valuable.' European Child & Adolescent Psychiatry