The Genetics of African Populations in Health and Disease: 84 (Cambridge Studies in Biological and Evolutionary Anthropology, Series Number 84)

Cambridge University Press, 12/19/2019
EAN 9781107072022, ISBN10: 1107072026

Hardcover, 348 pages, 25.4 x 17.8 x 2 cm
Language: English

The birthplace of modern humans, Africa, has the highest genetic diversity in the world, yet it remains vastly understudied. With biomedical research increasingly focused on human variation, studying the large population size and number of mutations in African genomes could unravel the complexity of phenotypic traits underlying the biology of our species and hold huge potential for scientific and medical advances. An initial chapter 'conceptualizes Africa', providing relevant terminology. The first section covers genetic history and population structure. The next section looks at the genetic basis of common infectious diseases, such as leishmaniasis, malaria and tuberculosis, with a final part considering common non-communicable diseases, such as diabetes, hypertension, obesity, heart disease and cancer. Gene environment interaction under globalization and the burden of diseases of lifestyle are included. For researchers and graduate students in biological anthropology, genetic anthropology, human and population genetics, and public health.

1. Reflections on conceptualizing Africa for biological studies with a historical component
a small essay Shomarka Omar Y. Keita
2. History and genetics in Africa
multidisciplinary efforts Shomarka Omar Y. Keita and Muntaser E. Ibrahim
3. Disease, selection, and evolution in the African landscape Muntaser Ibrahim and Endashaw Bekele
4. Genetic susceptibility to visceral leishmaniasis Hiba S. Mohamed, Muntaser E. Ibrahim and Jenefer M. Blackwell
5. Genetics of infection in Sub-Saharan Africa
what can the study of Mendelian immunodeficiency disorders contribute? Melanie Newport
6. Pharmacogenomics and infectious diseases in Africa
an evolutionary perspective Jennifer L. Baker, Daniel Shriner, Amy R. Bentley and Charles N. Rotimi
7. A glimpse into pharmacogenomics in Africa Collet Dandara and Alice Matimba
8. Genomics of cardiometabolic disorders in Sub-Saharan Africa Sally N. Adebamowo, Fasil Tekola-Ayele, Adebowale A. Adeyemo and Charles N. Rotimi
9. Breast cancer in African populations Konduru S. Sastry and Lotfi Chouchane
10. Socio-biological transition and cancer
prospects for Africa Sulma Mahmoud, Khalid O. Alfarouk, Ahmed M. Elhassan, Kamal Hamad and Muntaser E. Ibrahim
11. The genetic epidemiology of orphan diseases in North Africa Lilia Romdhane, Olfa Messaoud, Rym Kefi, Afaf Tiar, Ahlem Amouri, Mourad Mokni, Neji Tebib, Mohamed Zghal, Abdelhamid Barakat, Ahmed Houmeida, Mariem Bozguiya, Mohamed Othman, Ghada El Qameh and Sonia Abdelhak
12. Birth defects and genetic disease in Sub-Saharan Africa Ambroise Wonkam
13. Neurogenetic disorders in Africa
hereditary spastic paraplegia
a case study Liena E. O. Elsayed, Ammar E. M. Ahmed and Giovanni Stevanin.