Inflammatory Diseases of the Central Nervous System (Cambridge Medicine (Hardcover))

Cambridge University Press, 11/30/2009
EAN 9780521888745, ISBN10: 0521888743

Hardcover, 282 pages, 25.2 x 19.3 x 1.8 cm
Language: English

Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted – particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists.

Preface
Part I. Interactions Between the Immune and Nervous Systems
1. Effectors and determinants of the innate and adaptive immune responses Edgar Meinl and Hartmut Wekerle
2. Microglia
protective and pathogenic mediators Bevyn Jarrott and Karina Apricò
3. The role of dendritic cells in neuroinflammation Heather Donaghy, Edwina J. Wright and Anthony L. Cunningham
4. Negotiating the brain barriers
access of immune cells and pathogens into the CNS Britta Engelghardt
Part II. Autoimmunity
5. Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders Shaunu F. Roemer and Claudia F. Lucchinetti
6. Multiple sclerosis
neuroimmune crosstalk in acute and progressive stages of the disease Martin Kerschensteiner and Reinhard Hohlfeld
7. CD8+ T Cell-mediated autoimmune diseases in the CNS Lisa Walter and Matthew L. Albert
8. Acute disseminated encephalomyelitis
determinants and manifestations Eppie M. Yiu and Andrew J. Kornberg
9. Primary angiitis of the CNS and its mimics Tina Chadha, George F. Duna and Leonard H. Calabrese
Part III. Microbiological and Traumatic Challenges to the CNS
10. Acute viral encephalitis
role of the immune system in viral clearance from the CNS and in the generation of pathology David N. Irani and Natalie Prow
11. Chronic HIV infection of the CNS
role of the immune system in virological control and the generation of pathology Carolyn F. Orr and Bruce J. Brew
12. Brain inflammation during bacterial meningitis Trine H. Mogensen and Lars Østergaard
13. Parasitic infections of the brain
malaria and beyond Stephen J. Rogerson and Danny A. Milner Jr
14. Role of the inflammatory process in traumatic brain damage Cristina Morganti-Kossmann, Laveniya Satgunaseelan, Nicole Bye, Phuong Nguyen and Thomas Kossmann
Part IV. Therapy
15. HIV-associated neurocognitive disorders
clinical features and therapeutic challenges Nicoline Schiess and Justin C. McArthur
16. Role of immunomodulation in management of infections of the CNS Miles H. Beaman
17. Neuroinflammation
an emerging therapeutic target in neurological disease Joseph M. Antony and Christopher Power
Index.

'There is no doubt that this book can serve as a basic textbook for graduate students and clinicians who seek to understand mechanisms of CNS inflammation and who wish to gain insight that will suggest future avenues of intervention, or explain events associated with existing therapies. Even readers with only a basic background in immunology can benefit greatly from this book.' The Lancet