Molecular Endocrinology of Cancer (Cancer: Clinical Science in Practice)

Cambridge University Press, 4/14/2011
EAN 9780521159494, ISBN10: 0521159490

Paperback, 442 pages, 22.9 x 15.2 x 2.5 cm
Language: English

One third of human cancers have a hormonal basis. Breast cancer, the most common cancer of women, is increasing in incidence in many countries, as, in epidemic proportions, is prostate cancer, the second most common cancer of men. Concurrently, the development of molecular biology has led to a refinement of the definition of hormones to include the complex interaction between tumour cells and both locally and distantly secreted factors. This 1996 volume from the series Cancer: Clinical Science in Practice considers the many aspects of hormonally dependent cancer, including the molecular basis for the autocrine and paracrine regulation of cancer, molecular strategies for cancer detection, preventive strategies in limiting the epidemic of hormonally related cancers, and treatment approaches. The concise volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the application of biomedical science to the understanding and management of cancer.

Contributor list
Part I. The Regulation of Cancer
1. The type 1 growth factor receptor family, their ligands and their role in human cancers T. Rajkumar and W. J. Gullick
2. The fibroblast growth factor family and their receptors Pita Enriquez Harris and John K. Heath
3. The biological role of transforming growth factor beta in cancer development Bradley A. Arrick and Rik Derynck
4. Bombesin and its receptor Michael J. Seckl and Enrique Rozengurt
5. Gonadotrophin-releasing hormone and its receptor Karin A. Eidne and Lorraine Anderson
6. Cytokines T. Hamblin
Part II. The Prevention of Endocrine-Dependent Tumours
7. Familial Cancer Audrey D. Goddard and Donald M. Black
8. Diet Peter Boyle and Patrick Maisonneuve
9. Breast cancer
new biological approaches to treatment Robert B. Dickson and Robert Clarke
10. The biological basis for the treatment of prostate cancer Jonathan Waxman, Andrew Stubbs and Hardev Pandha
11. Carcinoid tumours S. Bloom and P. Hammond
Part III. Endocrine Complications of Cancer Treatment
12. Humoral hypercalcaemia John J. Wysolmerski and Arthur E. Braodus
13. Anaemia of cancer Carole B. Miller and Jerry L. Spivak
Index.