Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook
Cambridge University Press
Edition: Illustrated, 12/13/2007
EAN 9780521881159, ISBN10: 0521881153
Hardcover, 526 pages, 25.1 x 19.8 x 3 cm
Language: English
A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.
Preface
1. The structure and production of blood platelets Joseph E. Italiano, Jr
2. Platelet immunology
structure, functions and polymorphisms of membrane glycoproteins Yasuo Ikeda, Yumiko Matsubara and Tetsuji Kamata
3. Mechanisms of platelet activation Lawrence Brass and Timothy J. Stalker
4. Platelet priming Paolo Gresele, Emanuela Dalcinelli and Stafania Momi
5. Platelets and coagulation José A. López and Ian del Conde
6. Vessel-wall-derived substances affecting platelets Azad Raiesdana and Joseph Loscalzo
7. Platelet-Leukocyte-Endothelial cross talk Kevin J. Croce, Masashi Sakuma and Daniel I. Simon
8. Laboratory investigation of platelets Eduard Shantsila, Timothy Watson and Gregory Y. H. Lip
9. Clinical approach to the bleeding patient Jos Vermylen and Kathelijne Peerlinck
10. Thrombocytopenia James Bussel and Andrea Primiani
11. Reactive and clonal thrombocytosis Ayalew Tefferi
12. Congenital disorders of platelet function Marco Cattaneo
13. Acquired disorders of platelet function Michael H. Kroll and Amy A. Hassan
14. Platelet transfusion therapy Sherrill J. Slichter and Ronald G. Strauss
15. Clinical approach to the patient with thrombosis Brian G. Choi and Valentin Fuster
16. Pathophysiology of arterial thrombosis Juan José Badimon, Borja Ibanez and Gemma Vilahur
17. Platelets and atherosclerosis Stephan Lindemann and Meinrad Gawaz
18. Platelets in other thrombotic conditions David L. Green, Peter W. Marks and Simon Karpatkin
19. Platelets in respiratory disorders and inflammatory conditions Paolo Gresele, Stefania Momi, Simon C. Pitchford and Clive P. Page
20. Platelet pharmacology Dermot Cox
21. Antiplatelet therapy versus other antithrombotic strategies Nicolai Mejevoi, Catalin Boiangiu and Marc Cohen
22. Laboratory monitoring of antiplatelet therapy Paul Harrison and David Keeling
23. Antiplatelet therapy in cardiology Pierluigi Tricoc and Robert A. Harrington
24. Antiplatelet therapy in cerebrovascular disease James Castle and Gregory W. Albers
25. Antiplatelet treatment in peripheral arterial disease Raymond Verhaeghe and Peter Verhamme
26. Antiplatelet treatment of venous thromboembolism Menno V. Huisman, Jaapjan D. Snoep, Jouke T. Tamsma and Marcel M. C. Hovens
Index.
"A comprehensive clinical handbook...Each aspect of the platelet is covered in detail by leading experts in the field...The first 19 chapters contain a good mix of basic science and clinical medicine...The last seven chapters of the book cover [the development of antiplatelet drugs] in great detail. Tables and graphs summarizing the main clinical trials of antiplatelet therapy complement the information and recommendations presented in these treatment-oriented chapters...I enjoyed reading this book and believe that it will be a useful guide for residents, graduate students, physicians, and scientists." --New England Journal of Medicine