Aplastic Anemia: Pathophysiology and Treatment

Cambridge University Press, 11/11/1999
EAN 9780521641012, ISBN10: 0521641012

Hardcover, 403 pages, 25.5 x 19.3 x 2.5 cm
Language: English

This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as a detailed overview of the pathophysiology of the disease, the international team of authors cover all aspects of management, including the established approaches of bone marrow transplantation and immunosuppressive treatment, new approaches such as the use of hematopoietic growth factors and escalated immunosuppression, and controversial issues such as stem cell transplantation. Also included is an important international consensus document on treatment, and a final section concentrates on the inherited syndrome Fanconi's anemia. Detailed treatment guidelines are given, making this the definitive resource for hematologists and other clinicians involved in the management and supportive care of patients with aplastic anemia. Scientists interested in bone marrow failure will also find this an invaluable reference.

Part I. Pathophysiology of Acquired Aplastic Anemia
1. Stem cell defect in aplastic anemia J. C. W. Marsh and N. G. Testa
2. Cytokine abnormalities in aplastic anemia S. Kojima
3. Role of T-lymphocytes and apoptosis in pathophysiology of aplastic anemia S. Nakao
4. Role of apoptosis in pathophysiology of aplastic anemia F. M. Gibson, N. J. Philpott, J. C. W. Marsh and E. C. Gordon-Smith
5. Interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria G. Socié, J.-Y. Mary, H. Schrezenmeier and E. Gluckman
6. Aplastic anemia and other clonal disorders A. Raghavachar
Part II. Epidemiology and Clinical Features of Acquired Aplastic Anemia
7. Epidemiology and etiology of aplastic anemia H. Heimpel
8. Clinical presentation, natural course and prognostic factors P. Marin-Fernandez
Part III. Treatment of Acquired Aplastic Anemia
9. Supportive treatment of patients with severe aplastic anemia P. Ljungman
10. Immunosuppressive treatment of aplastic anemia A. Bacigalupo, H. Schrezenmeier and A. Tichelli
11. Role of cytokines in the treatment of aplastic anemia H. Schrezenmeier
12. HLA-identical sibling bone marrow transplantation to treat severe aplastic anemia S. R. McCann, J. R. Passweg, R. Storb and H. J. Deeg
13. Alternative donor bone marrow transplantation for severe acquired aplastic anemia J. M. Hows, J. V. Stone and B. M. Camitta
14. Treatment of children with acquired aplastic anemia A. Locasciulli
15. Long-term follow up of patients with aplastic anemia A. Tichelli and G. Socié
16. Guidelines for treatment of aplastic anemia (international consensus document)
Part IV. Fanconi's Anemia
17. Clinical features and diagnosis of Fanconi's anemia B. P. Alter
18. Genetic basis of Fanconi's anemia M. Buchwald and M. Carreau
19. Treatment of Fanconi's anemia E. Gluckman, G. Socié and P. Guardiola
20. Genetic correction of Fanconi's anemia J. M. Liu.

'This book provide a comprehensive and up to date concepts on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. The book is an excellent and enjoyable to read. The amateur who is satisfied with certainty will drive more from it than the impartial professional seeking and challenge. For the mahority of doctors and especially human hematologists, the book succeeds as an example of the precept 'first do not harm'. Aplastic Anemia is a super textbook and should be in the library of every scientist interested in this subject. I would also suggest the book to medical students.' Pio Conti, International Journal of Immunopathology and Pharmacology

'The book is up to date, and gives clear information on pathogenesis … this book is highly recommended and will remain valuable for many years to come.' Jill Hows, Hematological Oncology

Aplastic Anemia will be a useful reference work for clinicians who deal with this disorder and will be a good source of background information for those conducting basic research on the mechanisms.' Journal of the Royal Society of Medicine

'This reference is now the most up-to-date specialized reference on this subject. It will be of interest to and should be read by trainees in both pediatric and adult hematology and oncology.' Doody's Health Sciences Book Review Journal

'Aplastic anemia (AA) is a rare, complex, and often fatal disease that with appropriate therpy today has a high cure rate. This book is an excellent review of this disease with special emphasis on the different therapeutic modalities. It is a must read for all fellows in hematology/oncology, as well as other physicians taking care of patients with AA or Fanconi's anemia. It is also an important resource of information and will serve as a reference manual well into the new century.' Brynjar Vidarsson, Oncology/Karger