Cancer Metastasis: Biologic Basis and Therapeutics

Cambridge University Press, 4/25/2011
EAN 9780521887212, ISBN10: 0521887216

Hardcover, 660 pages, 27.9 x 21.5 x 3.1 cm
Language: English

Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

Overview
biology is the foundation of therapy
Part I. Basic Research
Introduction to basic research
Section 1. Models and Tools for Metastasis Studies
1. Animal models of cancer metastasis
2. Drosophila and zebrafish
genetic models for cancer metastasis
3. Computational models
4. Intravital microscopy to visualize invasion and metastasis
Section 2. Genes
5. Metastasis-promoting genes
6. The role of metastasis suppressor genes in metastasis
7. Stromal-derived factors that dictate organ-specific metastasis
8. Metastasis genes
epigenetics
9. Germline variation and other host determinants of metastatic potential
10. The influence of aging and cellular senescence on metastasis
Section 3. Various Properties of Cancer Cells
11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer
12. Apoptosis, anoikis, and senescence
13. Metastatic inefficiency and tumor dormancy
Section 4. Stromal Cells/Extracellular Matrix
14. Role of inflammation in metastatic progression
15. Proteolytic cascades in invasion and metastasis
16. Role of matrix metalloproteinases in tumor invasion and metastasis
17. Cell-derived microvesicles and metastasis
Section 5. Systemic Factors
18. Exploring the earliest steps in metastasis
the pre-metastatic niche
19. Growth regulatory pathways contributing to organ selectivity of metastasis
20. Determinants of organ-specific metastasis
21. Function and expression of the uPA/uPAR system in cancer metastasis
22. The lymphatics
on the route to cancer metastasis
Part II. Clinical Research
23. Introduction to clinical research
24. Sarcoma
25. Neuroblastoma
26. Retinoblastoma
27. Primary brain tumors and cerebral metastases
28. Head and neck cancer metastasis
29. Cutaneous melanoma
therapeutic approaches for metastatic disease
30. Gastric cancer metastasis
31. Metastatic pancreatic cancer
32. Metastasis of primary liver cancer
33. Advances in management of metastatic colorectal cancer
34. Lung cancer metastasis
35. Metastatic thyroid cancer
evaluation and treatment
36. Metastatic renal cell carcinoma
37. Bladder cancer
38. Bone complications of myeloma and lymphoma
39. Breast metastasis
40. Gynecologic malignancies
41. Prostate cancer metastasis
thoughts on biology and therapeutics
42. The biology and treatment of metastatic testicular cancer
43. Applications of proteomics to metastasis diagnosis and individualized therapy
44. Critical issues of research on circulating and disseminated tumor cells in cancer patients
45.  Lymphatic mapping and sentinel lymph node biopsy
46. Molecular imaging and metastasis
47. Preserving bone health in malignancy and complications of bone metastases
48. Role of platelets and thrombin in metastasis
Section 6. Therapies
49. Cancer nanotechnology offers great promise for cancer research and therapy
50. Metronomic chemotherapy for treatment of metastatic disease
from preclinical research to clinical trials
51. Immunotherapy
52. Discovery and development of drugs targeting tumor invasion and metastasis
53. The role of radiotherapy in the treatment of metastatic disease
54. Prospects for clinical trials of metastasis inhibitors.