Fed-Batch Cultures: Principles and Applications of Semi-Batch Bioreactors (Cambridge Series in Chemical Engineering)
Cambridge University Press, 4/22/2013
EAN 9780521513364, ISBN10: 0521513367
Hardcover, 471 pages, 25.9 x 18.3 x 2.8 cm
Language: English
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.
1. Introduction to fed-batch bioreactors
2. Idealised reactors and fed-batch reactors
3. Maximisation of reaction rates and fed-batch operation
4. Phenomena that favour fed-batch operations
5. Classification and characteristics of fed-batch cultures
6. Models based on mass balance equations
7. Non-equation-based models
8. Experimental determination of specific rates
9. Optimization via Pontryagin's maximum principle
10. Computational techniques
11. Optimization of single and multiple isothermal reactions
12. Optimization of fed-batch cultures for cell mass production
13. Optimization of fed-batch cultures for metabolites
14. Simple, intuitive adaptive optimization
15. Measurements, estimation and control
16. Feasibility assessment and implementable feed rates.