Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies

Cambridge University Press, 2009-09-24
EAN 9780521899376, ISBN10: 0521899370

Hardcover, 292 pages, 24.6 x 18.9 x 1.8 cm
Language: English

A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

'... an excellent book for understanding where the field stands today regarding sex hormones for the treatment of brain aging and dementia.' Doody's