Optogenetics: From Neuronal Function to Mapping and Disease Biology

Optogenetics: From Neuronal Function to Mapping and Disease Biology

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Cambridge University Press, 4/27/2017
EAN 9781107053014, ISBN10: 1107053013

Hardcover, 502 pages, 25.4 x 18 x 2.8 cm
Language: English
Originally published in English

Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson's disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

List of contributors
List of abbreviations
Part I. Optogenetics in Model Organisms
1. Introduction to optogenetics
from neuronal function to mapping and disease biology
2. Uncovering key neurons for manipulation in mammals
3. From connectome to function
using optogenetics to shed light on the Caenorhabditis elegans nervous system
4. From synapse to behaviour
optogenetic tools for investigation of the Caenorhabditis elegans nervous system
5. Using optogenetics in vivo to stimulate regeneration in Xenopus laevis
Part II. Opsin Biology, Tools and Technology Platform
6. Sodium and engineered potassium light-driven pumps
7. Simultaneous electrophysiology and optogenetic stimulation methods
8. Role of electrical activity in horizontal axon growth in the developing cortex
a time-lapse study using optogenetic stimulation
9. Development of an optogenetic tool to regulate protein stability in vivo
10. Photo-activatable nucleotide cyclases for synthetic photobiology applications
11. Bioluminescence activation of light-sensing molecules
Part III. Optogenetics in Neurobiology, Brain Circuits and Plasticity
12. Optogenetics for neurological disorders
what is a path to the clinic?
13. Optogenetic control of astroglia
14. Optogenetics for neurohormones and neuropeptides
focus on oxytocin
15. Optogenetic approaches to investigate brain circuits
16. Optogenetic mapping of neuronal connections and their plasticity
Part IV. Optogenetics in Learning, Neuro-psychiatric Diseases and Behavior
17. Optogenetics to study reward learning and addiction
18. Optogenetics and the dissection of neural circuits underlying depression and substance-use disorders
19. Optogenetics research in behavioral neuroscience
insights into the brain basis of reward learning and goal-directed behavior
20. An optogenetic approach to treat epilepsy
21. Using optogenetics and stem cells-derived neural engraftment techniques to restore lost motor function
Part V. Optogenetics in Vision Restoration and Memory
22. Optogenetics in treating retinal disease
23. Optogenetics for vision recovery
from traditional to designer optogenetic tools
24. A promise of vision restoration
25. Holographic Optical Neural Interfacing (HONI) with retinal neurons
26. Strategies for restoring vision by transducing a channelrhodopsin gene into retinal ganglion cells
27. Optogenetic dissection of a top-down prefrontal-to-hippocampus memory circuit
Part VI. Optogenetics in Sleep, Prosthetics and Epigenetics of Neurodegenerative Diseases
28. Optogenetic dissection of sleep-wake control
evidence for a thalamic control of sleep architecture
29. Optogenetics and auditory implants
30. Optogenetic stimulation for cochlear prosthetics
31. The role of amino acids in neurodegenerative and addictive diseases
32. Applications of combinations of deep brain stimulation and optogenetics
ethical considerations
an epilogue.