Perinatal Neuropathology
Cambridge University Press, 9/16/2021
EAN 9781107159792, ISBN10: 1107159792
Product Bundle, 458 pages, 22.1 x 9.8 x 6.4 cm
Language: English
Originally published in English
There is an increasing demand for high-standard fetal and infant neuropathology examinations. Novel imaging techniques, development of new diagnostic methods and advances in genetics have stimulated the interest in gaining additional knowledge on developmental, perinatal and neonatal neuropathology. Approaching the subject from a practical standpoint, diagnostic templates for reports are provided in this essential guide to aid clinicians with different areas of expertise. Each chapter will includes numerous high-quality images, accompanied by explanatory legends from the authors' own experiences. Covering autopsy and tissue processing techniques, the authors discuss a range of disorders such as neural tube defects, brain tumours, storage disorders and many others. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover. Compiling the latest advances in fetal and infant diagnostics and care, this book is a highly valuable educational resource.
Part I. Techniques and Practical Considerations
Approach to autopsy of perinatal nervous system
1. Clinical considerations
2. Imaging
3. External exam of fetus/infant
4. Autopsy and research consent
Ancillary studies
5. Microbiology
6. Cytogenetics
7. Metabolic studies
8. Toxicology
Prosection techniques
9. Brain
10. Spinal cord
11. Neuromuscular specimens
12. Eye specimens
Tissue selection
13. Selection of brain sreas for microscopic examination
14. Technical considerations in perinatal CNS tissue processing
15. Staining techniques
Reporting
16. Formulation of diagnosis
17. Reporting templates
18. Medicolegal Considerations
Part II. Human Nervous System Development
Neuroanatomic Site Development
19. Human nervous system development – embryonic and early fetal events
20. Cerebral cortex, including germinal matrix
21. White matter, including myelination
22. Cerebellum development of rhombic Lip, cerebellar cortex, dentate nucleus
23. Spinal cord
24. Skeletal muscle and peripheral nerve
25. Fetal and infant eye
Growth parameters
Head size and brain weight
Part III. Stillbirth
Autolysis and Artifacts
27. Autolysis and artefacts
Stillbirths
28. Stillbirth
Part IV. Disruptions/Hypoxic-Ischemic Injury
Cellular Responses
29. Neuronal death
30. Macroglial reactions
31. Inflammatory responses
Gray matter
32. Supratentorial grey matter damage and disruptions
33. Brainstem and spinal cord disruptions
white matter
34. Periventricular leukomalacia and diffuse white matter injury
Germinal matrix
35. Periventricular and intraventricular brain hemorrhage
Cerebellum
37. Cerebellar lesions
Part V. Malformations
Neural Tube Defects and Patterning Defects
37. Defects of neural tube Closure and axial mesodermal defects
38. Disorders of early midline patterning
Hydrocephalus
Fetal and perinatal hydrocephalus
Neuronal migration disorders
40. Cerebral cortical migration disorders
Genetic syndromes and phacomatoses
41. Fragile X syndrome
42. Down syndrome
43. Edwards's syndrome
44. Patau syndrome
45. Tuberous sclerosis complex
46. Sturge-weber syndrome
47. Neurocutaneous melanosis
Part VI. Congenital and Perinatal Brain Tumors
48. Congenital and perinatal brain Tumors
Part VII. Spinal and Neuromuscular Disorders
Arthrogryposis
49. Arthrogryposis
Spinal muscle atrophy (SMN AND NON-5Q SMA)
50. SMN and non-5q sMA,
Early-Onset hereditary neuropathies
51. CMT neuropathies
Congenital muscle disorders
52. Congenital myasthenic syndromes
53. Congenital muscular dystrophies
54. Congenital myopathies
55. Other congenital muscle diseases
Part VIII. Eye Disorders
Congenital Eye Disorders
56. Congenital eye malformations and Deformations
Part IX. Infections in Utero Infections
Congenital viral, bacterial, and parasitic infections
Peri- and postnatal infections
58. Meningitis and encephalitis
Part X. Metabolic/Toxic Disorders
Storage diseases
Lysosomal Disorders
60. Peroxisomal Disorders
Kernicterus
61. Kernicterus
Mitochondrial diseases
62.Mitochondrial diseases
Maternal toxin exposure
63. Ethanol and other agents
Part XI. Forensic Neuropathology
Trauma
64. Birth trauma
65. Accidental and non-accidental death
Sudden unexpected death in infancy and childhood
66. Sudden unexpected death in infancy and childhood.