The Clinical Use of Antipsychotic Plasma Levels: Stahl's Handbooks (Stahl's Essential Psychopharmacology Handbooks)
Cambridge University Press
Edition: New, 9/2/2021
EAN 9781009009898, ISBN10: 1009009893
Paperback, 404 pages, 19.8 x 12.9 x 2.4 cm
Language: English
Originally published in English
Clinicians recognize that monitoring psychotropic levels provides invaluable information to optimize therapy and track treatment adherence, but they lack formal training specifically focused on the use of plasma antipsychotic levels for these purposes. As new technologies emerge to rapidly provide these results, the opportunity to integrate this information into clinical care will grow. This practical handbook clarifies confusing concepts in the literature on use of antipsychotic levels, providing clear explanations for the logic underlying clinically relevant concepts such as the therapeutic threshold and the point of futility, and how these apply to individual antipsychotics. It offers accessible information on the expected correlation between dosages and trough levels, and also provides a clear explanation of how to use antipsychotic levels for monitoring oral antipsychotic adherence, and methods to help clinicians differentiate between poor adherence and variations in drug metabolism. An essential resource for psychiatrists, psychiatric nurse practitioners, and mental health professionals worldwide.
Preface
Introduction
1. Sampling times for oral and long-acting injectable agents
2. The therapeutic threshold and the point of futility
3. Level interpretation including laboratory reporting issues, responding to high plasma levels, special situations (hepatic dysfunction, renal dysfunction and hemodialysis, bariatric surgery)
4. Tracking oral antipsychotic adherence
5. What is an adequate antipsychotic trial – using plasma levels to optimize psychiatric response and tolerability
6. Important concepts about first generation antipsychotics
7. Haloperidol and haloperidol decanoate
8. Fluphenazine and fluphenazine decanoate
9. Perphenazine and perphenazine decanoate
10. Zuclopenthixol and zuclopenthixol decanoate
flupenthixol and flupenthixol decanoate
11. Chlorpromazine, loxapine, thiothixene, trifluoperazine
12. Important concepts about second generation antipsychotics
13. Clozapine
14. Risperidone oral and long-acting injectable, paliperidone oral and long-acting injectable
15. Olanzapine and olanzapine pamoate
16. Aripiprazole, aripiprazole monohydrate and aripiprazole lauroxil
17. Amisulpride, asenapine, lurasidone, brexpiprazole, cariprazine
Appendix Therapeutic threshold, point of futility, AGNP/ASCP laboratory alert level, and average oral concentration-dose relationships.